Products

ATG12 antibody

Synonyms:APG12 antibody, APG12L antibody
Catalogue No.:FNab10376Reativity:Human, Mouse
Host:RabbitTested Application:ELISA, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
ATG12 antibody
Catalogue No.
FNab10376
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
ATG12 autophagy related 12 homolog
Alternative Names
APG12 antibody, APG12L antibody
UniProt ID
O94817
Observed MW
48-50kd
Application
Tested Applications
ELISA, IHC
Recommended dilution
IHC: 1:50-1:200
Validated Images
Immunohistochemistry of paraffin-embedded human kidney using FNab10376(ATG12 antibody) at dilution of 1:50
Background
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.