Products

PP1A antibody

Synonyms:PP-1A antibody, PP1A antibody, PP1alpha antibody, PPP1A antibody, PPP1CA antibody
Catalogue No.:FNab10274Reativity:Human, Mouse
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
PP1A antibody
Catalogue No.
FNab10274
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
protein phosphatase 1, catalytic subunit, alpha isoform
Alternative Names
PP-1A antibody, PP1A antibody, PP1alpha antibody, PPP1A antibody, PPP1CA antibody
UniProt ID
P62136
Observed MW
38kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Validated Images
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab10274 (PP1A antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FNab10274 (PP1A Antibody) at dilution of 1:100
Background
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.