Products

anti- TRAF2 antibody

FNab10272 Catalogue No.
Synonyms
TRAF2, TRAP, TRAP3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Isotype
IgG
Tested Application
ELISA, WB
Product Information
Product Name
anti- TRAF2 antibody
Catalogue No.
FNab10272
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
Immunogen Information
Immunogen
TNF receptor-associated factor 2
Synonyms
TRAF2, TRAP, TRAP3
Observed MW
50-60 kDa
Application
Tested Application
ELISA, WB
Recommended dilution
WB: 1:500-1:2000
Uniprot information
UniProt ID
Q12933
Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab10272 (TRAF2 antibody) at dilution of 1:1000