HepG2 cells were subjected to SDS PAGE followed by western blot with FNab10264(IRF3 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human lung cancer using FNab10264(IRF3 antibody) at dilution of 1:50
Background
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.