Products
TRADD antibody
- Product Name
- TRADD antibody
- Catalogue No.
- FNab10260
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- TNFRSF1A-associated via death domain
- Alternative Names
- Hs.89862 antibody, TRADD antibody
- UniProt ID
- Q15628
- Observed MW
- 34 kDa, 27 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:200 - 1:2000; IHC: 1:50 - 1:500
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab10260( TRADD Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse heart tissue slide using FNab10260( TRADD antibody at dilution of 1:200
- Background
- The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A(By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
