Products

anti- TRADD antibody

FNab10260 Catalogue No.
Synonyms
Hs.89862, TRADD
Host
Rabbit
Reactivity
Human, Mouse, Rat
Isotype
IgG
Tested Application
ELISA, WB, IHC
Product Information
Product Name
anti- TRADD antibody
Catalogue No.
FNab10260
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A(By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
Immunogen Information
Immunogen
TNFRSF1A-associated via death domain
Synonyms
Hs.89862, TRADD
Observed MW
34 kDa, 27 kDa
Application
Tested Application
ELISA, WB, IHC
Recommended dilution
WB: 1:200 - 1:2000; IHC: 1:50 - 1:500
Uniprot information
UniProt ID
Q15628
Images
Immunohistochemistry of paraffin-embedded mouse heart tissue slide using FNab10260( TRADD antibody at dilution of 1:200
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab10260( TRADD Antibody) at dilution of 1:1000