Products

anti- PTP1B antibody

FNab10253 Catalogue No.
Synonyms
PTP 1B, PTP1B, PTPN1
Host
Rabbit
Reactivity
Human, Rat
Isotype
IgG
Tested Application
ELISA, WB, IHC
Product Information
Product Name
anti- PTP1B antibody
Catalogue No.
FNab10253
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
protein tyrosine phosphatase, non-receptor type 1
Synonyms
PTP 1B, PTP1B, PTPN1
Observed MW
50 kDa
Application
Tested Application
ELISA, WB, IHC
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Uniprot information
UniProt ID
P18031
Images
Immunohistochemistry of paraffin-embedded rat kidney using FNab10253(PTP1B antibody) at dilution of 1:50
jurkat cells were subjected to SDS PAGE followed by western blot with FNab10253(PTP1B antibody) at dilution of 1:1000