Products
RNF34 antibody
- Product Name
- RNF34 antibody
- Catalogue No.
- FNab10144
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- ring finger protein 34
- Alternative Names
- CARP 1 antibody, Caspase regulator CARP1 antibody, FYVE RING finger protein Momo antibody, hRFI antibody, RFI antibody, RIF antibody, RIFF antibody, ring finger protein 34 antibody, RING finger protein RIFF antibody, RNF34 antibody
- UniProt ID
- Q969K3
- Observed MW
- 41 kDa
Application
- Tested Applications
- WB
- Recommended dilution
- WB: 1:200-1:2000
Validated Images
Hela cells were subjected to SDS PAGE followed by western blot with FNab10144(RNF34 antibody) at dilution of 1:1000
- Background
- E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis(PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway(Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation(PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN(PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells(PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation(PubMed:25012219).
