Products

anti- NFKB1 antibody

FNab10143 Catalogue No.
Synonyms
DKFZp686C01211, DNA binding factor KBF1, EBP 1, KBF1, NF kappa B, NFKB p105, NFKB p50, NFKB1, NFKB1,p105, NFKB1,p105,p50, p105, p50
Host
Mouse
Reactivity
Human
Isotype
IgG2a
Tested Application
ELISA, WB, IF
Product Information
Product Name
anti- NFKB1 antibody
Catalogue No.
FNab10143
Size
100µg
Form
liquid
Purification
Protein A+G purification
Purity
≥95% as determined by SDS-PAGE
Host
Mouse
Clonality
monoclonal
Isotype
IgG2a
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.
Immunogen Information
Immunogen
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Synonyms
DKFZp686C01211, DNA binding factor KBF1, EBP 1, KBF1, NF kappa B, NFKB p105, NFKB p50, NFKB1, NFKB1,p105, NFKB1,p105,p50, p105, p50
Observed MW
105 kDa/50 kDa
Application
Tested Application
ELISA, WB, IF
Recommended dilution
WB: 1:500 - 1:3000; IF: 1:20 - 1:200
Uniprot information
UniProt ID
P19838
Images
Immunofluorescent analysis of HepG2 cells using FNab10143 (NFKB1 antibody) at dilution of 1:100
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab10143(NFKB1 antibody) at dilution of 1:1000