Products

NFKB1 antibody

Synonyms:DKFZp686C01211 antibody, DNA binding factor KBF1 antibody, EBP 1 antibody, KBF1 antibody, NF kappa B antibody, NFKB p105 antibody, NFKB p50 antibody, NFKB1 antibody, NFKB1 antibody, p105 antibody, NFKB1 antibody, p105 antibody, p50 antibody, p105 antibody, p50 antibody
Catalogue No.:FNab10143Reativity:Human
Host:MouseTested Application:ELISA, WB, IF
Clonality:monoclonalIsotype:IgG2a
  • SPECIFICATIONS
Product Name
NFKB1 antibody
Catalogue No.
FNab10143
Size
100μg
Form
liquid
Purification
Protein A+G purification
Purity
≥95% as determined by SDS-PAGE
Clonality
monoclonal
Isotype
IgG2a
Clone ID
1G4
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Alternative Names
DKFZp686C01211 antibody, DNA binding factor KBF1 antibody, EBP 1 antibody, KBF1 antibody, NF kappa B antibody, NFKB p105 antibody, NFKB p50 antibody, NFKB1 antibody, NFKB1 antibody, p105 antibody, NFKB1 antibody, p105 antibody, p50 antibody, p105 antibody, p50 antibody
UniProt ID
P19838
Observed MW
105 kDa/50 kDa
Application
Tested Applications
ELISA, WB, IF
Recommended dilution
WB: 1:500 - 1:3000; IF: 1:20 - 1:200
Validated Images
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab10143(NFKB1 antibody) at dilution of 1:1000
Immunofluorescent analysis of HepG2 cells using FNab10143 (NFKB1 antibody) at dilution of 1:100
Background
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.