Products

4EBP1 antibody

Synonyms:4E BP1 antibody, 4EBP1 antibody, BP 1 antibody, eIF4E binding protein 1 antibody, EIF4EBP1 antibody, PHAS I antibody
Catalogue No.:FNab10129Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC, IF
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
4EBP1 antibody
Catalogue No.
FNab10129
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
eukaryotic translation initiation factor 4E binding protein 1
Alternative Names
4E BP1 antibody, 4EBP1 antibody, BP 1 antibody, eIF4E binding protein 1 antibody, EIF4EBP1 antibody, PHAS I antibody
UniProt ID
Q13541
Observed MW
17 kDa
Application
Tested Applications
ELISA, WB, IHC, IF
Recommended dilution
WB: 1:500-1:1000; IHC: 1:50-1:200; IF: 1:50-1:200
Validated Images
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab10129(4EBP1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human breast cancer slide using FNab10129(4EBP1 Antibody) at dilution of 1:50
Background
Eukaryotic translation initiation factor 4E-binding protein 1(4EBP1), is a member of 4EBPs family, which regulate the translation of a subset of mRNA by competing with eIF4G for binding to eIF4E, thus preventing the assembly of the eIF4F complex. The eIF4F facilitates the recruitment of other translation initiation factors to form the complex and then initiates cap-dependent translation.4EBP1 also mediates the regulation of protein translation by growth factors, hormones and other stimuli that signal through the MAP kinase and mTORC1 pathways. There are three forms of 4EBP1, alpha, beta and gamma.