CD14 antibody

Category: Research Area:
Synonyms：CD14 antibody, CD14 molecule antibody
Catalogue No.：FNab10077Reactivity：Human
Host：RabbitTested Application：ELISA, IHC
Clonality：polyclonalIsotype：IgG
Manual MSDS
  • SPECIFICATIONS
Product Name
CD14 antibody
Catalogue No.
FNab10077
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
CD14 molecule
Alternative Names
CD14 antibody, CD14 molecule antibody
UniProt ID
P08571
Observed MW
50-55 kDa
Application
Tested Applications
ELISA, IHC
Recommended dilution
IHC: 1:20-1:200
Validated Images
Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab10077(CD14 Antibody) at dilution of 1:200
Background
Coreceptor for bacterial lipopolysaccharide(PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide(LPS)(PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response(PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway(PubMed:16880211).
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