Products

anti- CD14 antibody

FNab10077 Catalogue No.
Synonyms
CD14, CD14 molecule
Host
Rabbit
Reactivity
Human
Isotype
IgG
Tested Application
ELISA, IHC
Product Information
Product Name
anti- CD14 antibody
Catalogue No.
FNab10077
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Coreceptor for bacterial lipopolysaccharide(PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide(LPS)(PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response(PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway(PubMed:16880211).
Immunogen Information
Immunogen
CD14 molecule
Synonyms
CD14, CD14 molecule
Observed MW
50-55 kDa
Application
Tested Application
ELISA, IHC
Recommended dilution
IHC: 1:20-1:200
Uniprot information
UniProt ID
P08571
Images
Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab10077(CD14 Antibody) at dilution of 1:200