Products
DDR1 antibody
- Product Name
- DDR1 antibody
- Catalogue No.
- FNab10051
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- discoidin domain receptor tyrosine kinase 1
- Alternative Names
- CAK antibody, EDDR1 antibody, NEP antibody, NTRK4 antibody, PTK3A antibody, RTK6 antibody, TRKE antibody
- UniProt ID
- Q08345
- Observed MW
- 101 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:50-1:500
Validated Images
U87MG cells were subjected to SDS PAGE followed by western blot with FNab10051(DDR1 antibody) at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded rat testis tissue slide using FNab10051( DDR1 Antibody) at dilution of 1:200
- Background
- Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing(By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
