HeLa cells were subjected to SDS PAGE followed by western blot with FNab09997(CDC20 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human colon cancer using FNab09997(CDC20 antibody) at dilution of 1:100
Background
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome(APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.