Products

anti- Cdc20 antibody

FNab09997 Catalogue No.
Synonyms
CDC20, CDC20A, p55CDC
Host
Rabbit
Reactivity
Human
Isotype
IgG
Tested Application
ELISA, WB, IHC
Product Information
Product Name
anti- Cdc20 antibody
Catalogue No.
FNab09997
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome(APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Immunogen Information
Immunogen
cell division cycle 20 homolog
Synonyms
CDC20, CDC20A, p55CDC
Observed MW
55 kDa
Application
Tested Application
ELISA, WB, IHC
Recommended dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Uniprot information
UniProt ID
Q12834
Images
Immunohistochemistry of paraffin-embedded human colon cancer using FNab09997(CDC20 antibody) at dilution of 1:100
HeLa cells were subjected to SDS PAGE followed by western blot with FNab09997(CDC20 antibody) at dilution of 1:1000