Products
Phospho-VEGF Receptor 2 (Y1175) antibody
- Product Name
- Phospho-VEGF Receptor 2 (Y1175) antibody
- Catalogue No.
- FNab09964
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- A phospho specific peptide corresponding to residues surrounding Y1175 of human VEGF Receptor 2
- Alternative Names
- CD309 antibody, Fetal liver kinase 1 antibody, FLK 1 antibody, FLK1 antibody, KDR antibody, Kinase insert domain receptor antibody, VEGF Receptor 2 antibody, VEGFR antibody, VEGFR 2 antibody, VEGFR2 antibody
- UniProt ID
- P35968
- Observed MW
- 250 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:1000; IHC: 1:50 - 1:100
Validated Images
HUVE cells were subjected to SDS PAGE followed by western blot with FNab09964 at dilution of 1:600
Immunohistochemistry of paraffin-embedded human breast carcinoma tissue slide using FNab09964 at dilution of 1:50
- Background
- KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.
