Products
CASP14 antibody
- Product Name
- CASP14 antibody
- Catalogue No.
- FNab09900
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- CASP14
- Alternative Names
- CASP14 antibody, ARCI12 antibody, caspase-14 antibody
- UniProt ID
- P31944
- Observed MW
- 30 kDa
Application
- Tested Applications
- ELISA, WB, IF
- Recommended dilution
- WB: 1:500 - 1:2000; IF: 1:50 - 1:200
Validated Images
293T cells were subjected to SDS PAGE followed by western blot with FNab09900( CASP14 antibody) at dilution of 1:1000
Immunofluorescent analysis of MCF-7 cells using FNab09900( CASP14 antibody) at dilution of 1:100.
- Background
- This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
