Products

beta-Catenin antibody

Synonyms:b cat antibody, Beta catenin antibody, beta-Catenin antibody, Catenin beta 1 antibody, CTNNB antibody, CTNNB1 antibody, PRO2286 antibody, β catenin antibody, β-catenin antibody
Catalogue No.:FNab09871Reativity:Human, Mouse, Rat, Pig
Host:MouseTested Application:ELISA, IF, WB, IHC, IP
Clonality:monoclonalIsotype:IgG1
  • SPECIFICATIONS
Product Name
beta-Catenin antibody
Catalogue No.
FNab09871
Size
100μg
Form
liquid
Purification
protein A+G purified
Purity
≥95% as determined by SDS-PAGE
Clonality
monoclonal
Isotype
IgG1
Clone ID
5D7
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
catenin(cadherin-associated protein), beta 1, 88kDa
Alternative Names
b cat antibody, Beta catenin antibody, beta-Catenin antibody, Catenin beta 1 antibody, CTNNB antibody, CTNNB1 antibody, PRO2286 antibody, β catenin antibody, β-catenin antibody
UniProt ID
P35222
Observed MW
90 kDa
Application
Tested Applications
ELISA, IF, WB, IHC, IP
Recommended dilution
WB: 1:2000-1:20000; IP: 1:1000-1:5000; IHC: 1:200-1:1000; IF: 1:20-1:500
Validated Images
A431 cells were subjected to SDS PAGE followed by western blot with FNab09781(B-catenin antibody) at dilution of 1:5000
IP Result of anti-beta-Catenin (IP:FNab09871, 4ug; Detection:FNab09871 1:500) with mouse liver tissue lysate 6400ug.
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab09781(B-catenin Antibody) at dilution of 1:200
Background
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.