Products
RANKL antibody
- Product Name
- RANKL antibody
- Catalogue No.
- FNab09838
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG1
- Clone ID
- 4F11
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- tumor necrosis factor (ligand) superfamily, member 11
- Alternative Names
- CD254 antibody, hRANKL2 antibody, ODF antibody, OPGL antibody, OPTB2 antibody, Osteoprotegerin ligand antibody, RANKL antibody, sOdf antibody, TNFSF11 antibody, TRANCE antibody
- UniProt ID
- O14788
- Observed MW
- 35 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:1000-1:5000
Validated Images
Hela cells were subjected to SDS PAGE followed by western blot with FNab09838(RANKL antibody) at dilution of 1:3000
- Background
- TNFSF11 also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL induces osteoclast formation through its receptor, RANK, which transduces signals by recruiting adaptor molecules, such as the TNF receptor-associated factor (TRAF) family of proteins. RANKL was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. RANKL was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.
