HT-29 cell lysate were subjected to SDS PAGE followed by western blot with FNab09807(TSHB antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded mouse lung tissue slide using FNab09807( TSH beta antibody) at dilution of 1:100
Immunofluorescence analysis of U2OS cells using FNab09807( TSH beta antibody). Blue: DAPI for nuclear staining.
Background
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants.