Products
WTAP antibody
- Product Name
- WTAP antibody
- Catalogue No.
- FNab09530
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG1
- Clone ID
- 9D4
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- Wilms tumor 1 associated protein
- Alternative Names
- DKFZp686F20131 antibody, Female lethal(2)D homolog antibody, hFL(2)D antibody, KIAA0105 antibody, WT1 associated protein antibody, WTAP antibody
- UniProt ID
- Q15007
- Observed MW
- 49 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:1000-1:10000; IHC: 1:50-1:500
Validated Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab09530(WTAP Antibody) at dilution of 1:2000
Immunohistochemistry of paraffin-embedded human cervical cancer using FNab09530(WTAP antibody) at dilution of 1:50
- Background
- Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine(m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle(PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator(PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability(PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes(PubMed:17095724).
