Products
WRN antibody
- Product Name
- WRN antibody
- Catalogue No.
- FNab09524
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- Werner syndrome, RecQ helicase-like
- Alternative Names
- DKFZp686C2056 antibody, DNA helicase antibody, RecQ like type 3 antibody, Exonuclease WRN antibody, RecQ protein like 2 antibody, RECQ3 antibody, RECQL2 antibody, RECQL3 antibody, WRN antibody
- UniProt ID
- Q14191
- Observed MW
- 162-200 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:200-1:1000
Validated Images
MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab09524(WRN Antibody) at dilution of 1:300
- Background
- Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A(By similarity). Plays a role in double-strand break repair after gamma-irradiation.
