Products
WDR24 antibody
- Product Name
- WDR24 antibody
- Catalogue No.
- FNab09488
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- WD repeat domain 24
- Alternative Names
- C16orf21 antibody, DKFZp434F054 antibody, JFP7 antibody, WD repeat domain 24 antibody, WDR24 antibody
- UniProt ID
- Q96S15
- Observed MW
- 102 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:200-1:2000; IF: 1:10-1:100; IHC: 1:20-1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab09488(WDR24 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human ovary using FNab09488(WDR24 antibody) at dilution of 1:50
- Background
- As a component of the GATOR subcomplex GATOR2, functions as an activator of the amino acid-sensing branch of the TORC1 pathway(PubMed:23723238, PubMed:27166823). Inhibits the GATOR1 subcomplex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway(PubMed:23723238). Functions downstream of and is regulated by amino acid sensors like SESN2(PubMed:26449471, PubMed:26586190). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux(PubMed:27166823).
