HL-60 cells were subjected to SDS PAGE followed by western blot with FNab09467(WAPL; WAPAL antibody) at dilution of 1:300
Background
The wings apart-like(WAPL, or WAPAL) protein was originally identified as a gene product that potentially regulates heterochromatin organization in Drosophila melanogaster. Human WAPL is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability.