HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09387(VDAC2 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human kidney using FNab09387(VDAC2 antibody) at dilution of 1:100
Background
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.