Products
USP5 antibody
- Product Name
- USP5 antibody
- Catalogue No.
- FNab09340
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- ubiquitin specific peptidase 5(isopeptidase T)
- Alternative Names
- Deubiquitinating enzyme 5 antibody, Isopeptidase T antibody, ISOT antibody, Ubiquitin thiolesterase 5 antibody, USP5 antibody
- UniProt ID
- P45974
- Observed MW
- 93 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:1000-1:2000
Validated Images
A549 cells were subjected to SDS PAGE followed by western blot with FNab09340(USP5 antibody) at dilution of 1:1000
- Background
- Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
