Products

anti- USP11 antibody

FNab09306 Catalogue No.
Synonyms:
Deubiquitinating enzyme 11, Ubiquitin thiolesterase 11, UHX1, USP11
Host:
Rabbit
Reactivity:
Human
Isotype:
IgG
Tested Application:
ELISA, WB, IHC, IP
Product Information
Product Name
anti- USP11 antibody
Catalogue No.
FNab09306
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains(PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome(PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains(in vitro)(PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation(PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks(PubMed:15314155, PubMed:20233726).
Immunogen Information
Immunogen
ubiquitin specific peptidase 11
Synonyms
Deubiquitinating enzyme 11, Ubiquitin thiolesterase 11, UHX1, USP11
Observed MW
110 kDa
Application
Tested Application
ELISA, WB, IHC, IP
Recommended dilution
WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500
Uniprot information
UniProt ID
P51784
Images
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab09306(USP11 Antibody) at dilution of 1:50
IP Result of anti-USP11 (IP:FNab09306, 4ug; Detection:FNab09306 1:2000) with HEK-293 cells lysate 2400ug.
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab09306(USP11 antibody) at dilution of 1:1000