Products
USP11 antibody
- Product Name
- USP11 antibody
- Catalogue No.
- FNab09306
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- ubiquitin specific peptidase 11
- Alternative Names
- Deubiquitinating enzyme 11 antibody, Ubiquitin thiolesterase 11 antibody, UHX1 antibody, USP11 antibody
- UniProt ID
- P51784
- Observed MW
- 110 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab09306(USP11 antibody) at dilution of 1:1000
IP Result of anti-USP11 (IP:FNab09306, 4ug; Detection:FNab09306 1:2000) with HEK-293 cells lysate 2400ug.
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab09306(USP11 Antibody) at dilution of 1:50
- Background
- Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains(PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome(PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains(in vitro)(PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation(PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks(PubMed:15314155, PubMed:20233726).
