Products

anti- USP11 antibody

FNab09305 Catalogue No.
Synonyms
Deubiquitinating enzyme 11, Ubiquitin thiolesterase 11, UHX1, USP11
Host
Rabbit
Reactivity
Human
Isotype
IgG
Tested Application
ELISA, WB, IHC, IP, IF
Product Information
Product Name
anti- USP11 antibody
Catalogue No.
FNab09305
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains(PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome(PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains(in vitro)(PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation(PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks(PubMed:15314155, PubMed:20233726).
Immunogen Information
Immunogen
ubiquitin specific peptidase 11
Synonyms
Deubiquitinating enzyme 11, Ubiquitin thiolesterase 11, UHX1, USP11
Observed MW
110 kDa
Application
Tested Application
ELISA, WB, IHC, IP, IF
Recommended dilution
WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:1000-1:10000; IF: 1:20-1:200
Uniprot information
UniProt ID
P51784
Images
Immunohistochemistry of paraffin-embedded human brain tissue slide using FNab09305(USP11 Antibody) at dilution of 1:50
IP Result of anti-USP11 (IP:FNab09305, 4ug; Detection:FNab09305 1:300) with HEK-293 cells lysate 1480ug.
A549 cells were subjected to SDS PAGE followed by western blot with FNab09305(USP11 antibody) at dilution of 1:1000