Products
Uromodulin antibody
- Product Name
- Uromodulin antibody
- Catalogue No.
- FNab09294
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- uromodulin
- Alternative Names
- ADMCKD2 antibody, FJHN antibody, HNFJ antibody, MCKD2 antibody, THGP antibody, THP antibody, UMOD antibody, uromodulin antibody
- UniProt ID
- P07911
- Observed MW
- 55-70 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1:20-1:500; IP: 1:200-1:2000
Validated Images
human heart tissue were subjected to SDS PAGE followed by western blot with FNab09294(UMOD antibody) at dilution of 1:400
IP Result of anti-Uromodulin (IP:FNab09294, 4ug; Detection:FNab09294 1:500) with mouse brain tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human kidney using FNab09294(UMOD antibody) at dilution of 1:50
- Background
- Uromodulin, also known as THP(Tamm-Horsfall glycoprotein), is the most abundant protein excreted in the urine under physiological conditions. Uromodulin is synthesized by kidney and localizes in cells lining the ascending limb of Henle and distal convoluted tubule. Uromodulin has been linked to water/electrolyte balance and to kidney innate immunity. Also, studies in knockout mice demonstrated that it has a protective role against urinary tract infections and renal stone formation. Mutations in the gene encoding uromodulin lead to rare autosomal dominant diseases, collectively referred to as uromodulin-associated kidney diseases.(PMID: 21654721)
