HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09134(TXNRD2 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human endometrial cancer using FNab09134(TXNRD2 antibody) at dilution of 1:50
Background
This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described.