HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab08658( THAP1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human colon cancer using FNab08658(THAP1 antibody) at dilution of 1:50
Immunofluorescence analysis of A549 cells using FNab08658(THAP1 antibody)
Background
The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed.