anti- TGF-beta 1 antibody

FNab08638 Catalogue No.

Synonyms:: CED, DPD1, LAP, TGF beta 1, TGFB, TGFB1, TGFbeta, TGF-beta1, TGF-β1
Host:: Rabbit
Reactivity:: Human, Mouse, Rat
Isotype:: IgG
Tested Application:: ELISA, WB, IHC

Manual

Product Information

Product Name: anti- TGF-beta 1 antibody
Catalogue No.: FNab08638
Size: 100µg
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

: TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease(CED) which known as progressive diaphyseal dysplasia 1(DPD1).

Immunogen Information

Immunogen: transforming growth factor, beta 1
Synonyms: CED, DPD1, LAP, TGF beta 1, TGFB, TGFB1, TGFbeta, TGF-beta1, TGF-β1
Observed MW: 44 kDa

Application

Uniprot information

Images

Image 1: Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab08638(TGFB1 Antibody) at dilution of 1:200
Image 4: A549 cells were subjected to SDS PAGE followed by western blot with FNab08638(TGFB1 Antibody) at dilution of 1:600