human heart tissue were subjected to SDS PAGE followed by western blot with FNab08399(SURF1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human heart using FNab08399(SURF1 antibody) at dilution of 1:50
Background
This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency.