Products
STK36 antibody
- Product Name
- STK36 antibody
- Catalogue No.
- FNab08335
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- serine/threonine kinase 36, fused homolog(Drosophila)
- Alternative Names
- KIAA1278 antibody
- UniProt ID
- Q9NRP7
- Observed MW
- 144 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab08335(STK36 antibody) at dilution of 1:300
IP Result of anti-STK36 (IP:FNab08335, 4ug; Detection:FNab08335 1:500) with mouse testis tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human prostate using FNab08335(STK36 antibody) at dilution of 1:50
- Background
- Serine/threonine protein kinase which plays an important role in the sonic hedgehog(Shh) pathway by regulating the activity of GLI transcription factors(PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization(PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur(PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function(By similarity). Essential for construction of the central pair apparatus of motile cilia.
