Products
SOST antibody
- Product Name
- SOST antibody
- Catalogue No.
- FNab08119
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- sclerosteosis
- Alternative Names
- Sclerostin|SOST antibody
- UniProt ID
- Q9BQB4
- Observed MW
- 30 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Validated Images
Hela cells were subjected to SDS PAGE followed by western blot with FNab08119( SOST Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver tissue slide using FNab08119( SOST Antibody) at dilution of 1:50
- Background
- Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
