Products

SMURF1 antibody

Synonyms:KIAA1625 antibody
Catalogue No.:FNab08046Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
SMURF1 antibody
Catalogue No.
FNab08046
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
SMAD specific E3 ubiquitin protein ligase 1
Alternative Names
KIAA1625 antibody
UniProt ID
Q9HCE7
Observed MW
83-90 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab08046(SMURF1 antibody) at dilution of 1:800
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab08046(SMURF1 Antibody) at dilution of 1:50
Background
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes(PubMed:23999003).