Products
SFPQ antibody
- Product Name
- SFPQ antibody
- Catalogue No.
- FNab07785
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)
- Alternative Names
- Splicing factor antibody, proline- and glutamine-rich|100 kDa DNA-pairing protein (hPOMp100)|DNA-binding p52/p100 complex antibody, 100 kDa subunit|Polypyrimidine tract-binding protein-associated-splicing factor (PSF antibody, PTB-associated-splicing factor)|SFPQ|PSF antibody
- UniProt ID
- P23246
- Observed MW
- 115 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:1000; IHC: 1:50 - 1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab07785(SFPQ antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human stomach using FNab07785(SFPQ antibody) at dilution of 1:50
- Background
- SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types. This antibody is a rabbit polyclonal antibody raised against the N-terminal of human SFPQ.
