HeLa cells were subjected to SDS PAGE followed by western blot with FNab07151(RBBP5 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse liver using FNab07151(RBBP5 antibody) at dilution of 1:50
Background
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.