Products
PSMD14 antibody
- Product Name
- PSMD14 antibody
- Catalogue No.
- FNab06886
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- proteasome(prosome, macropain) 26S subunit, non-ATPase, 14
- Alternative Names
- PAD1 antibody, POH1 antibody, PSMD14 antibody, rpn11 antibody
- UniProt ID
- O00487
- Observed MW
- 35 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1:20-1:200
Validated Images
human heart tissue were subjected to SDS PAGE followed by western blot with FNab06886(PSMD14 antibody) at dilution of 1:400
Immunohistochemistry of paraffin-embedded human colon cancer using FNab06886(PSMD14 antibody) at dilution of 1:50
- Background
- Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks(DSBs): acts as a regulator of non-homologous end joining(NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
