Products
OPRL1 antibody
- Product Name
- OPRL1 antibody
- Catalogue No.
- FNab05997
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- opiate receptor-like 1
- Alternative Names
- OOR antibody, ORL1 antibody
- UniProt ID
- P41146
- Observed MW
- 45 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab05997(OPRL1 antibody) at dilution of 1:500
IP Result of anti-OPRL1 (IP:FNab05997, 4ug; Detection:FNab05997 1:500) with SH-SY5Y cells lysate 2000ug.
Immunohistochemistry of paraffin-embedded human gliomas using FNab05997(OPRL1 antibody) at dilution of 1:100
- Background
- G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins(G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
