Products

NR1H3 antibody

Synonyms:Liver X receptor alpha antibody, LXR a antibody, LXRA antibody, NR1H3 antibody, Oxysterols receptor LXR alpha antibody, RLD 1 antibody
Catalogue No.:FNab05835Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
NR1H3 antibody
Catalogue No.
FNab05835
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
nuclear receptor subfamily 1, group H, member 3
Alternative Names
Liver X receptor alpha antibody, LXR a antibody, LXRA antibody, NR1H3 antibody, Oxysterols receptor LXR alpha antibody, RLD 1 antibody
UniProt ID
Q13133
Observed MW
48 kDa
Application
Tested Applications
ELISA, WB
Recommended dilution
WB: 1:500-1:5000
Validated Images
Sp2/0 cells were subjected to SDS PAGE followed by western blot with FNab05835(NR1H3 antibody) at dilution of 1:1000
Background
Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism(By similarity). Exhibits a ligand-dependent transcriptional activation activity(PubMed:25661920).