Products
NHP2 antibody
- Product Name
- NHP2 antibody
- Catalogue No.
- FNab05727
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- NHP2 ribonucleoprotein homolog
- Alternative Names
- NHP2 antibody, NHP2P antibody, NOLA2 antibody, snoRNP protein NHP2 antibody
- UniProt ID
- Q9NX24
- Observed MW
- 17-20kd
Application
- Tested Applications
- ELISA, WB, IHC, IF, IP
- Recommended dilution
- WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
Validated Images
Hela cells were subjected to SDS PAGE followed by western blot with FNab05727(NHP2 antibody) at dilution of 1:1000
IP result of anti-NHP2(IP: FNab05727, 4μg; Detection: FNab05727 1:1000 ) with HepG2 cells lysate 3600μg.
Immunohistochemistry of paraffin-embedded human prostate cancer using FNab05727(NHP2 antibody) at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using FNab05727 (NPH2 Antibody) at dilution of 1:25
- Background
- Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein(H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase(TERT) holoenzyme.
