Products

NCAM1/CD56 antibody

Synonyms:CD56 antibody, MSK39 antibody, N CAM 1 antibody, NCAM antibody, NCAM 1 antibody, NCAM1 antibody
Catalogue No.:FNab05575Reativity:Human, Mouse
Host:MouseTested Application:ELISA, WB, IHC
Clonality:monoclonalIsotype:IgG2a
  • SPECIFICATIONS
Product Name
NCAM1/CD56 antibody
Catalogue No.
FNab05575
Size
100μg
Form
liquid
Purification
Protein A+G purification
Purity
≥95% as determined by SDS-PAGE
Clonality
monoclonal
Isotype
IgG2a
Clone ID
0D10
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
neural cell adhesion molecule 1
Alternative Names
CD56 antibody, MSK39 antibody, N CAM 1 antibody, NCAM antibody, NCAM 1 antibody, NCAM1 antibody
UniProt ID
P13591
Observed MW
140 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:1000-1:10000; IHC: 1:200-1:1000
Validated Images
fetal human brain tissue were subjected to SDS PAGE followed by western blot with FNab05575(NCAM1 Antibody) at dilution of 1:4000
Immunohistochemistry of paraffin-embedded human small cell lung carcinoma tissue slide using FNab05575(NCAM1 Antibody) at dilution of 1:800 Heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Background
Neural cell adhesion molecule 1(NCAM1, also known as CD56) is a cell adhesion glycoprotein of the immunoglobulin(Ig) superfamily. It is a multifunction protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM1 is expressed on human neurones, glial cells, skeletal muscle cells, NK cells and a subset of T cells, and the expression is observed in a wide variety human tumors, including myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, and NK/T cell lymphomas. Three major isoforms of NCAM1, with molecular masses of 120, 140, and 180 kDa, are generated by alternative splicing of mRNA(PMID: 9696812). The glycosylphosphatidylinositol(GPI)-anchored NCAM120 and the transmembrane NCAM140 and NCAM180 consist of five Ig-like domains and two fibronection-type III repeats(FNIII). All three forms can be posttranslationally modified by addition of polysialic acid(PSA)(PMID: 14976519). Several other isofroms have also been described(PMID: 1856291).