MBD2 antibody

Synonyms:Methyl-CpG-binding domain protein 2|Demethylase (DMTase)|Methyl-CpG-binding protein MBD2|MBD2 antibody
Catalogue No.:FNab05034Reactivity:Human, Rat
Host:RabbitTested Application:ELISA, WB
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
  • FIGURES
  • CONDITIONS
Product Name
MBD2 antibody
Catalogue No.
FNab05034
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
methyl-CpG binding domain protein 2
Alternative Names
Methyl-CpG-binding domain protein 2|Demethylase (DMTase)|Methyl-CpG-binding protein MBD2|MBD2 antibody
UniProt ID
Q9UBB5
Observed MW
43-45 kDa
Application
Tested Applications
ELISA, WB
Recommended dilution
WB: 1:500-1:2000
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab05034(MBD2 antibody) at dilution of 1:1000
Background
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.