Products
INSIG2 antibody
- Product Name
- INSIG2 antibody
- Catalogue No.
- FNab04334
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- insulin induced gene 2
- UniProt ID
- Q9Y5U4
- Observed MW
- 30 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
rat liver tissue were subjected to SDS PAGE followed by western blot with FNab04334(INSIG2 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver tissue slide using FNab04334(INSIG2 Antibody) at dilution of 1:50
- Background
- Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins(SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.
