Products

INSIG1 antibody

Synonyms:CL 6 antibody, INSIG 1 antibody, INSIG1 antibody, insulin induced gene 1 antibody, Insulin induced gene 1 protein antibody
Catalogue No.:FNab04333Reativity:Human, Mouse
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
INSIG1 antibody
Catalogue No.
FNab04333
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
insulin induced gene 1
Alternative Names
CL 6 antibody, INSIG 1 antibody, INSIG1 antibody, insulin induced gene 1 antibody, Insulin induced gene 1 protein antibody
UniProt ID
O15503
Observed MW
28-31; 66-70 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
A549 cells were subjected to SDS PAGE followed by western blot with FNab04333(INSIG1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver using FNab04333(INSIG1 antibody) at dilution of 1:50
Background
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins(SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation(ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.