Products
IL-17 antibody
- Product Name
- IL-17 antibody
- Catalogue No.
- FNab04225
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG1
- Clone ID
- 5E2
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- interleukin 17A
- Alternative Names
- CTLA 8 antibody, CTLA8 antibody, IL 17 antibody, IL 17A antibody, IL17 antibody, IL-17 antibody, IL17A antibody, interleukin 17A antibody
- UniProt ID
- Q16552
- Observed MW
- 18 kDa
Application
- Tested Applications
- ELISA, WB, FC
- Recommended dilution
- WB: 1:500-1:1000
Validated Images
U-937 cells were subjected to SDS PAGE followed by western blot with FNab04225(IL-17 antibody) at dilution of 1:500
- Background
- IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2(PTGS2/COX-2), as well as enhance the production of nitric oxide(NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.
