Products
IL12B antibody
- Product Name
- IL12B antibody
- Catalogue No.
- FNab04219
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- interleukin 12B
- Alternative Names
- CLMF antibody, CLMF p40 antibody, CLMF2 antibody, IL 12 subunit p40 antibody, IL 12B antibody, IL12B antibody, Interleukin 12 subunit beta antibody, NKSF antibody, NKSF2 antibody
- UniProt ID
- P29460
- Observed MW
- 37 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:500-1:2000
Validated Images
A549 cells were subjected to SDS PAGE followed by western blot with FNab04219(IL12B Antibody) at dilution of 1:1000
- Background
- Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
