HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab03796(HDAC2 antibody) at dilution of 1:1000
IP Result of anti-HDAC2 (IP:FNab03796, 3ug; Detection:FNab03796 1:1000) with mouse testis tissue lysate 10000ug.
Immunohistochemistry of paraffin-embedded human prostate cancer using FNab03796(HDAC2 antibody) at dilution of 1:100
Background
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.