HL-60 cells were subjected to SDS PAGE followed by western blot with FNab03737(GZMB antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human lymphoma using FNab03737(GZMB antibody) at dilution of 1:100
Background
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases(aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3,-7,-9 and 10 to give rise to active enzymes mediating apoptosis.