Products

GZMB antibody

Synonyms:CCPI antibody, CGL 1 antibody, CGL1 antibody, CSP B antibody, CSPB antibody, CTLA1 antibody, CTSGL1 antibody, Endogenous granzyme B antibody, Granzyme B antibody, GZMB antibody, HLP antibody, SECT antibody
Catalogue No.:FNab03737Reativity:Human
Host:RabbitTested Application:ELISA, WB, IHC, IF
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
GZMB antibody
Catalogue No.
FNab03737
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
granzyme B
Alternative Names
CCPI antibody, CGL 1 antibody, CGL1 antibody, CSP B antibody, CSPB antibody, CTLA1 antibody, CTSGL1 antibody, Endogenous granzyme B antibody, Granzyme B antibody, GZMB antibody, HLP antibody, SECT antibody
UniProt ID
P10144
Observed MW
33 kDa
Application
Tested Applications
ELISA, WB, IHC, IF
Recommended dilution
WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500
Validated Images
HL-60 cells were subjected to SDS PAGE followed by western blot with FNab03737(GZMB antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human lymphoma using FNab03737(GZMB antibody) at dilution of 1:100
Background
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases(aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3,-7,-9 and 10 to give rise to active enzymes mediating apoptosis.