GSPT2 antibody

Category: Research Area:
Synonyms：Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b antibody, eRF3b)|G1 to S phase transition protein 2 homolog|GSPT2|ERF3B antibody
Catalogue No.：FNab03681Reactivity：Human, Mouse, Rat
Host：RabbitTested Application：ELISA, WB, IHC
Clonality：polyclonalIsotype：IgG
Manual MSDS
  • SPECIFICATIONS
Product Name
GSPT2 antibody
Catalogue No.
FNab03681
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
G1 to S phase transition 2
Alternative Names
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b antibody, eRF3b)|G1 to S phase transition protein 2 homolog|GSPT2|ERF3B antibody
UniProt ID
Q8IYD1
Observed MW
69 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab03681(GSPT2 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human colon cancer using FNab03681(GSPT2 antibody) at dilution of 1:100
Background
Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome-and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay(NMD) of mRNAs containing premature stop codons.
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