Products

anti- EXOSC5 antibody

FNab02905 Catalogue No.
Synonyms:
CML28, RRP46
Host:
Rabbit
Reactivity:
Human, Rat
Isotype:
IgG
Tested Application:
ELISA, WB, IHC
Product Information
Product Name
anti- EXOSC5 antibody
Catalogue No.
FNab02905
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs) , and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
Immunogen Information
Immunogen
exosome component 5
Synonyms
CML28, RRP46
Observed MW
28-30 kDa
Application
Tested Application
ELISA, WB, IHC
Recommended dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Uniprot information
UniProt ID
Q9NQT4
Images
Immunohistochemistry of paraffin-embedded human breast cancer using FNab02905 (EXOSC5 antibody) at dilution of 1:50
K-562 cells were subjected to SDS PAGE followed by western blot with FNab02905 (EXOSC5 antibody) at dilution of 1:500