Products

Endostatin antibody

Synonyms:Endostatin antibody
Catalogue No.:FNab02762Reativity:Human
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
Endostatin antibody
Catalogue No.
FNab02762
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
collagen, type XVIII, alpha 1
Alternative Names
Endostatin antibody
UniProt ID
P39060
Observed MW
19 kDa, 27 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
human liver tissue were subjected to SDS PAGE followed by western blot with FNab02762(Endostatin, COL18A1 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human liver using FNab02762(Endostatin, COL18A1 antibody) at dilution of 1:50
Background
Endostatin is a naturally-occurring 20-kDa C-terminal fragment derived from COL18A1(also named as KNO). It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. It potently inhibits endothelial cell proliferation and inhibits endothelial cell angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. Endostatin is a broad spectrum angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor(bFGF/FGF-2) and vascular endothelial growth factor(VEGF).